Tenofovir Nephrotoxicity: Focusing Research Questions and Putting Them into Clinical Context
نویسندگان
چکیده
منابع مشابه
Putting molecular disease research into physiological context.
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At first glance, conceptual representations (e.g., our internal notion of the object "lemon") seem static; we have the impression that there is something that the concept lemon "means" (a sour, yellow, football-shaped citrus fruit) and that this meaning does not vary. Research in semantic memory has traditionally taken this "static" perspective. Consequently, only effects demonstrated across a ...
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Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit signi...
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PHOTO COURTESY OF RICK GABER N ature makes impressive use of a relatively small number of proteins. The same signaling pathways and transcription factors are often reused in different contexts to direct diverse developmental processes, and understanding how proteins show the right activity at the right time and place is a fundamental question for developmental biologists. Lee et al. reveal how ...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2008
ISSN: 0022-1899,1537-6613
DOI: 10.1086/524091